br Fig A In vivo
Fig. 8. (A) In vivo fluorescence imaging of the MDA-MB-231 orthotopic tumor-bearing nude mice at 2, 4, 6 and 12 h following injection with PMDIs and DINPs. (B) Ex vivo fluorescence imaging of the harvested normal tissues and tumors at 12 h after injection. (C) (D) In vivo photothermal imaging and quantitative analysis of tumor photothermal efficacy at 6 h post injection. (E) ROI analysis of fluorescent intensities in normal tissues and tumors.
Fig. 9. Evaluation of in vivo antitumor efficacy and anti-metastasis effects in orthotopic MDA-MB-231-luc tumor-bearing nude mice. (A) In vivo bioluminescence and tumor images at 20 d post-administration of saline, DOX, PMDs, ICG + L, DINPs + L, PMIs + L, DOX + ICG + L and PMDIs + L. (B) Tumor growth curves. (C) Mice morbidity-free survival period after different treatments (5 mice per group). (D) Photos of India-ink staining for whole lungs and H&E staining for tumor, kidney, lung, spleen, liver, and 1821-12-1 slices harvested after different treatments. White arrows indicate the visible metastatic nodules. Yellow and red arrows indicate the lung and liver metastases, respectively. Scale bar: 1 mm. (E) Changes in mice body weight after different treatments. ** p < 0.01 versus the control. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Appendix A. Supplementary data
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Accepted Manuscript
Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
Yu Mi, Feifei Yang, Cameron Bloomquist, Youli Xia, Bo Sun,
Yanfei Qi, Kyle Wagner, Stephanie Montgomery, Tian Zhang,
Andrew Z. Wang
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ACCEPTED MANUSCRIPT
Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
Yu Mi
Laboratory of Nano- and Translational Medicine
Carolina Center for Cancer Nanotechnology Excellence
Carolina Institute of Nanomedicine
Lineberger Comprehensive Cancer Center
Department of Radiation Oncology
University of North Carolina at Chapel Hill
Feifei Yang
Institute of Medicinal Plant Development (IMPLAD)
Chinese Academy of Medical Sciences & Peking Union Medical College
Q3 Haidian District, Beijing, P. R. China
Cameron Bloomquist
School of Pharmacy
University of North Carolina at Chapel Hill
Chapel Hill, NC 27599, USA
Youli Xia
Department of Genetics
University of North Carolina at Chapel Hill