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  • br Fig A In vivo

    2020-08-07


    Fig. 8. (A) In vivo fluorescence imaging of the MDA-MB-231 orthotopic tumor-bearing nude mice at 2, 4, 6 and 12 h following injection with PMDIs and DINPs. (B) Ex vivo fluorescence imaging of the harvested normal tissues and tumors at 12 h after injection. (C) (D) In vivo photothermal imaging and quantitative analysis of tumor photothermal efficacy at 6 h post injection. (E) ROI analysis of fluorescent intensities in normal tissues and tumors.
    Fig. 9. Evaluation of in vivo antitumor efficacy and anti-metastasis effects in orthotopic MDA-MB-231-luc tumor-bearing nude mice. (A) In vivo bioluminescence and tumor images at 20 d post-administration of saline, DOX, PMDs, ICG + L, DINPs + L, PMIs + L, DOX + ICG + L and PMDIs + L. (B) Tumor growth curves. (C) Mice morbidity-free survival period after different treatments (5 mice per group). (D) Photos of India-ink staining for whole lungs and H&E staining for tumor, kidney, lung, spleen, liver, and 1821-12-1 slices harvested after different treatments. White arrows indicate the visible metastatic nodules. Yellow and red arrows indicate the lung and liver metastases, respectively. Scale bar: 1 mm. (E) Changes in mice body weight after different treatments. ** p < 0.01 versus the control. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
    Appendix A. Supplementary data
    References
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    12 Accepted Manuscript
    Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
    Yu Mi, Feifei Yang, Cameron Bloomquist, Youli Xia, Bo Sun, Yanfei Qi, Kyle Wagner, Stephanie Montgomery, Tian Zhang,
    Andrew Z. Wang r> Please cite this article as: Y. Mi, F. Yang, C. Bloomquist, et al., Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion, Advanced Drug Delivery Reviews, https://doi.org/10.1016/j.addr.2019.07.009
    This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors 1821-12-1 may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
    ACCEPTED MANUSCRIPT
    Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion
    Yu Mi
    Laboratory of Nano- and Translational Medicine
    Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center
    Department of Radiation Oncology University of North Carolina at Chapel Hill
    Feifei Yang
    Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences & Peking Union Medical College Q3 Haidian District, Beijing, P. R. China
    Cameron Bloomquist School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill, NC 27599, USA
    Youli Xia Department of Genetics University of North Carolina at Chapel Hill